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Methylation support; Homocysteine metabolism; Cardiovascular health; Cognitive support; Bone health
Adults seeking focused methylation support for daily wellness or those with low intake of methyl-donor nutrients.
Take 3 capsules two times daily; taking with meals may improve tolerance.
Gluten Free
Betaine donates methyl groups that help remethylate homocysteine to methionine, supporting normal methylation processes.
Caution: May affect those on low-methionine diets or sensitive to large methyl donor intakes; start with the suggested serving to gauge tolerance.
Methylcobalamin serves as a cofactor for methionine synthase, which uses methyl groups to convert homocysteine to methionine.
Caution: High-potency B12 can mask unrecognized low folate status; take as directed and consider consistency rather than large sporadic doses.
L-5-MTHF provides the bioactive folate form that supplies methyl groups to homocysteine via methionine synthase.
Caution: High folate intake may interact with certain medications and can hide signs of low vitamin B12; use as directed.
Pyridoxal 5'-phosphate is a coenzyme for cystathionine beta-synthase, which helps channel homocysteine through the transsulfuration pathway.
Caution: Excessive vitamin B6 over time may cause tingling or numbness; do not exceed suggested use.
Betaine and methylcobalamin provide methyl groups and enzymatic support for remethylating homocysteine to methionine. L-5-MTHF supplies the active folate needed for this step, while pyridoxal 5'-phosphate supports the alternate transsulfuration route. Together these pathways help maintain balanced methylation activity.
Label Warning: If pregnant, consult a health-care practitioner before use.
Who should be cautious: People on high-dose vitamin B supplements or with B-vitamin sensitivities may want to discuss dosing with a clinician. Those with a history of kidney stones or on a low-methionine/low-protein plan may wish to review betaine intake with a healthcare provider.
Storage: Store tightly sealed in a cool, dry place.
Many users mention feeling more energetic after starting the supplement.
Reviewers say the active forms of folate and B12 seem to absorb well and feel effective.
A few users suggest starting slowly due to possible sensitivity to methylated forms.
This product is guaranteed authentic and backed by our easy returns & refunds policy. Details
A B Complex provides a balanced intake of B vitamins, including Methylfolate, supporting overall energy and metabolic health.
AI generated. Not medical advice.
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Supports methylation for healthy heart, blood vessels, brain, and bones.
Methyl-Guard contains betaine, 5-MTHF, methyl-B12, and P5P to support healthy methylation for cardiovascular, cognitive, and bone health. Methylation helps maintain healthy homocysteine levels.
Take 3 capsules two times daily or as recommended by your health-care practitioner.
Hypromellose (derived from cellulose) capsule, silicon dioxide, calcium citrate, calcium laurate.
Use only if bottle is sealed. Store tightly sealed in a cool, dry place.
If pregnant, consult your health-care practitioner before using this product.
Manufactured in the USA using U.S. & imported ingredients.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by iHerb.
| Supplement facts | ||
| Serving Size: Three Capsules | ||
| Servings Per Container: 60 | ||
| Three Capsules Contain: | %DV | |
| Vitamin B6 (as Pyridoxal 5'-Phosphate) | 20.4 mg | 1,200% |
| Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 2 mg DFE | 500% |
| Vitamin B12 (as Methylcobalamin) | 1.2 mg | 50,000% |
| Betaine Anhydrous (Trimethylglycine) | 1.8 g | * |
| *Daily Value (DV) not established. †This product uses Gnosis S.p.A's L-5-Methyltetrahydrofolic Acid, Glucosamine salt (Quatrefolic®). | ||
