Taking B1 for a few years now, tired of the taste and smell of the body from the thiamine HCl, I finally found that thiamin pyrophosphate (TPP) is a better option for those not capable to produce and change B1 in its active form, it saved me from the weird smell, and I feel it has better potency than when taking the 300mg of thiamine HCl tablet. People complained about the taste but I didn't find it unpleasant, didn't have GI changes or other side effects, especially the ones I had to deal with for years from the other form. It melts slowly, which is good. Still taking the fat-soluble forms, benfotiamine and allitiamine, but TPP covers my need for the water-soluble B1. When oxalate in our bodies gets too high, it causes dysbiosis, we cannot degrade oxalate, we are reliant upon our microbes in the gut to degrade oxalate. Oxalate degrading microbes in the gut (termed oxalotrophic microbes) can be damaged by antibiotics and antifungals, and other hits, also after certain infections, someone may actually develop a new oxalate problem. The protein called oxalate oxidoreductase (OOR) metabolizes oxalate using thiamine pyrophosphate (TPP), and the protein oxalyl coenzyme A decarboxylase is dependent upon thiamine. It requires thiamine which, if it is in other forms, must be converted into thiamine diphosphate (TPP). This is the primary form of thiamine that microbes will make and use. I found this product a rare and huge help for my kidney and other B1-related problems, I hope it will stay on the market, I didn't find this ingredient anywhere else to buy it and it is worrying.
